Complete Record - Heirs of Hippocrates No. 2309

SELMAR ASCHHEIM (1878-1965) Schwangerschaftsdiagnose aus dem Harn (durch Hormonnachweis). (In Klinische Wochenschrift. Vol. 7 (1928), pp. 8-9, 1404-1411, 1453-1457.) 29 cm.

Several days after implanting pieces of the anterior lobe of the pituitary gland in immature female mice, Aschheim and Zondek (see No. 2326) found significant changes in the ovaries and uteri of the mice and that the mice had developed a distinct estrus cycle. The two researchers concluded that the pituitary gland had caused the ovaries to experience early and rapid development. Using young female mice, they then demonstrated the presence of a substance that stimulated rapid development of the ovaries during the first days of pregnancy. This substance entered the urine, which previously had been free of it. It was therefore possible to determine pregnancy by examining the urine. In these three papers, published in January and July 1928, the authors give the first report on the development of their test for the diagnosis of pregnancy.

See Related Record(s): 2326

Cited references: Garrison-Morton 6222

Gift of John Martin, M.D.